Identification of multi-drug resistance gene (MDR1) in equine ileum
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منابع مشابه
Expression of multi drug resistance (MDR1) gene in human promyelocytic leukemia cell line selected with vincristine
MDR1 mediated drug resistance is one of the main problems for some cancer chemotherapies. Vincristine (VCR) is an effective drug used in clinical treatment of acute leukemias. The concentration of VCR was stepwise increased (1-50 nM) in the cell culture media of HL60 cells (AML cell line). The viability of cells was determined and the expression of MDR1 gene was studied by using reverse transcr...
متن کاملRegulatory Role of Human AP-endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of Multi Drug Resistance (MDR1) Gene
Running Title: APE1 modulates YB-1-mediated activation of MDR1 ABSTRACT The human AP-endonuclease (APE1/Ref-1), a central enzyme involved in repair of oxidative base damage and DNA strand breaks, has a second activity as a transcriptional regulator that binds to several transacting factors. APE1 overexpression is often observed in tumor cells, and confers resistance to various anticancer drugs;...
متن کاملExpression of multi-drug resistance genes (mdr1, mrp1, bcrp) in primary oral squamous cell carcinoma.
UNLABELLED The expression of resistance genes can cause the ineffectiveness of chemotherapeutics for the treatment of cancer. Therefore, known resistance genes were investigated in oral squamous cell carcinoma (OSCC) and the results were compared with clinico-pathological findings. MATERIALS AND METHODS Fresh frozen samples of 45 primary OSCC were investigated for the expression of mdr1 (p-gl...
متن کامل[Polymorphisms of the multiple drug resistance gene (MDR1) in Mapuche, Mestizo and Maori populations in Chile].
BACKGROUND There are significant differences in drug responses among different ethnic groups. The multidrug transporter P-gp, encoded by the MDR1 gene, plays a key role in determining drug bioavailability, and an association between a polymorphism in exon 26 (C3435T) and lower P-gp expression has been found. The co-segregation of this polymorphism with the polymorphism in exon 12 (C1236T) and i...
متن کاملMulti-drug resistance (MDR1) gene expression in de novo acute leukemia cells: correlations with CD surface markers and treatment outcome.
One important mechanism of drug resistance in acute leukemia is the overexpression of the multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P-glycoprotein. To estimate the incidence and role of MDR1 gene expression in patients with acute leukemia, we investigated the expression of MDR1 by using the RT-PCR method in blast cells from 40 cases of de novo acute leukem...
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ژورنال
عنوان ژورنال: Ciência Rural
سال: 2006
ISSN: 0103-8478
DOI: 10.1590/s0103-84782006000100048