Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds
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چکیده
منابع مشابه
Development of the mechanical properties of engineered skin substitutes after grafting to full-thickness wounds.
Engineered skin substitutes (ESSs) have been reported to close full-thickness burn wounds but are subject to loss from mechanical shear due to their deficiencies in tensile strength and elasticity. Hypothetically, if the mechanical properties of ESS matched those of native skin, losses due to shear or fracture could be reduced. To consider modifications of the composition of ESS to improve homo...
متن کاملEpidermal lipid metabolism of cultured skin substitutes during healing of full-thickness wounds in athymic mice.
Cultured epidermal keratinocytes provide an abundant supply of biologic material for wound treatment. Because restoration of barrier function is a definitive criterion for efficacy of wound closure and depends on the lipids present in the epidermis, we analyzed lipid composition of the epidermis in cultured skin substitutes in vitro and after grafting to athymic mice. The cultured skin substitu...
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There is a clinical need for skin substitutes to replace full-thickness skin loss. Our group has developed a bilayered skin substitute produced from the patient's own fibroblasts and keratinocytes referred to as Self-Assembled Skin Substitute (SASS). After cell isolation and expansion, the current time required to produce SASS is 45 days. We aimed to optimize the manufacturing process to standa...
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Introduction: Positive effects of topical application of honey on open skin wounds have been observed, Mast cell are playing role in normal wound healing and its disturbances but the role of mast cells in wound healing in existence of honey is uncertain. Objective: The aim of this investigation was to study the effects of two times per day topical application of honey on the number of mas...
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Wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. Simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. In this study we aimed to determine the effect of simvastatin on wound healing process in...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0213325