Identification of Fungal Sphingolipid C9-methyltransferases by Phylogenetic Profiling
نویسندگان
چکیده
منابع مشابه
Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling.
Niemann-Pick type C (NPC)1 is a rare neurodegenerative disease for which treatment options are limited. A major barrier to development of effective treatments has been the lack of validated biomarkers to monitor disease progression or serve as outcome measures in clinical trials. Using targeted metabolomics to exploit the complex lipid storage phenotype that is the hallmark of NPC1 disease, we ...
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C9-methylated glucosylceramide is a fungus-specific sphingolipid. This lipid is a major membrane component in the cell and is thought to play important roles in the growth and virulence of several fungal species. To investigate the importance of the methyl branch of the long-chain base in glucosylceramides in pathogenic fungi, we identified and characterized a sphingolipid C9-methyltransferase ...
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MOTIVATION Abundance profiling (also called 'phylogenetic profiling') is a crucial step in understanding the diversity of a metagenomic sample, and one of the basic techniques used for this is taxonomic identification of the metagenomic reads. RESULTS We present taxon identification and phylogenetic profiling (TIPP), a new marker-based taxon identification and abundance profiling method. TIPP...
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متن کاملPhylogenetic Profiling
Phylogenetic profiling involves the study of the occurrence of gene families across fully sequenced genomes. For any gene, it is possible to create a phylogenetic profile which encodes the presence or absence of homologs of the gene across organisms. The comparison of phylogenetic profiles may be used to measure the evolutionary distance between organisms leading to the reconstruction of phylog...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m512864200