Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

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Identification of DNA fragments carrying ecotropic proviruses of AKR mice.

The proviruses of the N-tropic, ecotropic virus (AKV) of AKR mice (Akv-1, Akv-2) have been studied by the Southern gel--filter transfer technique. These proviruses can be detected by cleavage of cell DNA by BamHI endonuclease, which yields characteristic subgenomic DNA fragments upon cleavage of this type of provirus. Proviruses integrated into different sites in the mouse genome can be resolve...

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Restricted expression of ecotropic virus by thymocytes of leukemia- resistant (AKR X NZB)F1 mice

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Precise identification of endogenous proviruses of NFS/N mice participating in recombination with moloney ecotropic murine leukemia virus (MuLV) to generate polytropic MuLVs.

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Brief Definitive Report RESTRICTED EXPRESSION OF ECOTROPIC VIRUS BY THYMOCYTES OF LEUKEMIA-RESISTANT (AKR × NZB)F1 MICE*

The thymus has a central role in the pathogenesis of l eukemia in AKR mice. Thymectomy great ly reduces the incidence of l eukemia (1). Moreover, v i r tua l ly all t issues of AKR mice express high t i ters of Gross (ecotropic, N-tropic) virus (2), but neoplasms develop regular ly only in the thymus. The thymus of the AKR mouse is also the site of two impor tant virological changes tha t occur...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1979

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.76.9.4554