Identification of deleterious recessive haplotypes and candidate deleterious recessive mutations in Japanese Black cattle
نویسندگان
چکیده
منابع مشابه
Obstruction of adaptation in diploids by recessive, strongly deleterious alleles.
Recessive deleterious mutations are common, causing many genetic disorders in humans and producing inbreeding depression in the majority of sexually reproducing diploids. The abundance of recessive deleterious mutations in natural populations suggests they are likely to be present on a chromosome when a new adaptive mutation occurs, yet the dynamics of recessive deleterious hitchhikers and thei...
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In Montbéliarde cattle two candidate mutations on bovine chromosomes 19 and 29 responsible for embryonic lethality have been detected. Montbéliarde bulls have been introduced into Vorderwald cattle to improve milk and fattening performance. Due to the small population size of Vorderwald cattle and the wide use of a few Montbéliarde bulls through artificial insemination, inbreeding on Montbéliar...
متن کاملDeleterious Recessive Genes in Dairy Bulls Selected at Random.
HE genetics of farm mammals have not been investigated in a manner T comparable to the intensive studies made, during the last forty years, with Drosophila, laboratory rodents, and chickens. Nevertheless, a large number of mutant genes have been reported in farm mammals. These mutants have been discovered more or less by chance when sufficient inbreeding has brought them to light. Many more hav...
متن کاملDetection of Haplotypes Associated with Prenatal Death in Dairy Cattle and Identification of Deleterious Mutations in GART, SHBG and SLC37A2
The regular decrease of female fertility over time is a major concern in modern dairy cattle industry. Only half of this decrease is explained by indirect response to selection on milk production, suggesting the existence of other factors such as embryonic lethal genetic defects. Genomic regions harboring recessive deleterious mutations were detected in three dairy cattle breeds by identifying ...
متن کاملSex and deleterious mutations.
The evolutionary advantage of sexual reproduction has been considered as one of the most pressing questions in evolutionary biology. While a pluralistic view of the evolution of sex and recombination has been suggested by some, here we take a simpler view and try to quantify the conditions under which sex can evolve given a set of minimal assumptions. Since real populations are finite and also ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-86225-y