Identification of an Xiap-Like Pseudogene on Mouse Chromosome 7
نویسندگان
چکیده
منابع مشابه
Identification of an Xiap-Like Pseudogene on Mouse Chromosome 7
The most thoroughly characterized mammalian IAP is XIAP/BIRC4, which can inhibit caspases 9, 3 and 7, but may also regulate apoptosis through interactions with other proteins such as Smac/DIABLO, HtrA2/Omi, XAF1, TAK1, cIAP1, and cIAP2.High throughput sequencing of the mouse genome revealed the existence of a gene resembling Xiap/Birc4 on mouse chromosome 7. To confirm the existence of this gen...
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The Apc mouse model of colorectal cancer provides a discrete, quantitative measurement of tumor multiplicity, allowing for robust quantitative trait locus analysis. This advantage has previously been used to uncover polymorphic modifiers of the Min phenotype: Mom1, which is partly explained by Pla2g2a; Mom2, a spontaneous mutant modifier; and Mom3, which was discovered in an outbred cross. Here...
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Departments of Pediatrics and Communicable Diseases, Human Genetics, and Internal Medicine, University of Michigan, Ann Arbot, Michigan 48109, USA Laboratory of Gene Transfer, National Center for Human Genome Research, 49 Convent Drive, Room 3A14, Bethesda, Maryland, 20892-4470, USA Diagnostic Development Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0008078