Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
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چکیده
منابع مشابه
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is m...
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It is known that evolutionarily new genes can rapidly evolve essential roles in fundamental biological processes. Nevertheless, the underlying molecular mechanism of how they acquire their novel transcriptional pattern is less characterized except for the role of cis-regulatory evolution. Epigenetic modification offers an alternative possibility. Here, we examined how histone modifications have...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.08.008