Identification and preliminary characterization of novel B3-type metallo-β-lactamases
نویسندگان
چکیده
منابع مشابه
Identification and Characterization of Metallo-β-Lactamases Producing Pseudomonas aeruginosa Clinical Isolates in University Hospital from Zanjan Province, Iran
Background: Infectious by Pseudomonas aeruginosa has spread worldwide and metallo-beta-lactamases (MBL) are being reported with increasing frequency. The aim of this study was to investigate the antibiotic susceptibility and distribution of blaVIM and blaIMP genes in P. aeruginosa isolates from Zanjan Province of Iran. Methods: A total of 70 P. aeruginosa isolates were identified from patients ...
متن کاملMetallo-β-Lactamases and Aptamer-Based Inhibition
An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the hydrolysis of the β-lactam bond of this class of antibiotics, by pathogenic bacteria such as Bacillus cereus, are rendering them useless. Some inh...
متن کاملMolecular characterization of IMP-type metallo-β-lactamases among multidrug-resistant Achromobacter xylosoxidans.
OBJECTIVES To analyse the metallo-β-lactamase (MBL) genes and their genetic environments in clinical isolates of Achromobacter xylosoxidans. METHODS From January 2004 to December 2010, four MBL-producing, multidrug-resistant (MDR) A. xylosoxidans strains were isolated and analysed at a tertiary care university hospital in Japan. Species-level identification was confirmed by 16S ribosomal RNA ...
متن کاملidentification and characterization of metallo-β-lactamases producing pseudomonas aeruginosa clinical isolates in university hospital from zanjan province, iran
background: infectious by pseudomonas aeruginosa has spread worldwide and metallo-beta-lactamases (mbl) are being reported with increasing frequency. the aim of this study was to investigate the antibiotic susceptibility and distribution of blavim and blaimp genes in p. aeruginosa isolates from zanjan province of iran. methods: a total of 70 p. aeruginosa isolates were identified from patients ...
متن کاملIdentification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data
BACKGROUND Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and lack of clinically useful inhibitors, make them a particularly problematic class of antibiotic resistance determinants. We hypothesized that there...
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ژورنال
عنوان ژورنال: American Journal of Molecular Biology
سال: 2013
ISSN: 2161-6620,2161-6663
DOI: 10.4236/ajmb.2013.34026