IC-P-099: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI

CSF Biomarkers

With an ever growing population of aged individuals who are at risk of developing Alzheimer’s disease (AD), there is an urgent need for a sensitive, specific and preferably non-invasive diagnostic standard of disease progression. Diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accura...

Ventricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline.

Ideal biomarkers of Alzheimer's disease (AD) should correlate with accepted measures of pathology in the cerebrospinal fluid (CSF); they should also correlate with, or predict, future clinical decline, and should be readily measured in hundreds to thousands of subjects. Here we explored the utility of automated 3D maps of the lateral ventricles as a possible biomarker of AD. We used our multi-a...

[CSF dynamics of hydranencephaly].

Eighteen infants and children with typical congenital hydranencephaly were studied by pneumoen cephalography, water-soluble contrast ventriculography, and cisternography (radioisotope or metri zamide). Pneumoencephalography and ventriculography suggested that the aqueduct was obstructed or markedly stenotic in all cases. Cisternography demonstrated blocks at the aqueduct and at the level of the...

CSF flow measurement in syringomyelia.

BACKGROUND AND PURPOSE CSF circulation has been reported to represent a major factor in the pathophysiology of syringomyelia. Our purpose was to determine the CSF flow patterns in spinal cord cysts and in the subararachnoid space in patients with syringomyelia associated with Chiari I malformation and to evaluate the modifications of the flow resulting from surgery. METHODS Eighteen patients ...

Diagnostic performance of CSF biomarkers in CJD