منابع مشابه
Targeted Delivery of siRNA
Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier. To overcome these barriers several strategies have been developed, such as chemical modifications of siRNA, viral nucleic acid d...
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Cancer stem cells (CSCs) are suggested as the most dominant causes of recurrence due to their permanent self-renewal and resistance to common cancer treatment in glioblastoma multiform (GBM) which is recognized as the most malignant of brain tumor. It has been indicated that Retinoblastoma-binding protein 5 (RBBP5), a main part of Mixed lineage leukemia protein-1 (MLL1), plays a significant rol...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2014
ISSN: 1433-7851
DOI: 10.1002/anie.201308368