منابع مشابه
Hypoxia-sensitive pathways in inflammation-driven fibrosis.
Tissue injury can occur for a variety of reasons, including physical damage, infection, and ischemia. The ability of tissues to effectively recover from injury is a cornerstone of human health. The healing response in tissues is conserved across organs and typically involves distinct but overlapping inflammatory, proliferative, and maturation/resolution phases. If the inflammatory phase is not ...
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Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory response, autophagy, and epithelial barrier integrity. Moreover, epithelial oxygen tension plays a critical role in intestinal inflammation and resolution in IBD. The intestines have a dynam...
متن کاملTargeting Hypoxia-induced Inflammation.
I N the current issue of ANESTHESIOLOGY, an article by Kim et al. from the research laboratory of H. Thomas Lee, M.D., Ph.D., investigates strategies to dampen ischemiadriven inflammation of the kidneys and subsequent multiorgan failure using experimental models of acute kidney injury (AKI). In fact, one of the leading causes of morbidity and mortality in surgical patients is perioperative orga...
متن کاملIntestinal inflammation in cystic fibrosis.
BACKGROUND There is controversy about whether the inflammatory response observed in the cystic fibrosis (CF) lung occurs secondary to bacterial infection or is caused by a dysregulation of the inflammatory response associated with the basic cellular defect of CF. AIMS To study the inflammatory response in the gastrointestinal tract of children with CF; and to investigate whether there is incr...
متن کاملCrosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability
The barrier function of the intestine is essential for maintaining the normal homeostasis of the gut and mucosal immune system. Abnormalities in intestinal barrier function expressed by increased intestinal permeability have long been observed in various gastrointestinal disorders such as Crohn's disease (CD), ulcerative colitis (UC), celiac disease, and irritable bowel syndrome (IBS). Imbalanc...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2017
ISSN: 0022-3751
DOI: 10.1113/jp274350