Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

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Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans.

We investigated the expression and effects of hypoxia-inducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after...

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Thromboangiitis obliterans.

Case presentation: A 39-year-old male smoker with a 2-year history of calf discomfort on ambulation culminating in left femoral-to-peroneal artery bypass presented with right leg discomfort and recurrent painful subcutaneous nodules on his feet and calves. Biopsy of a nodule from his right foot was interpreted as vasculitis with thrombosis and fibrinoid necrosis in subcutaneous vessels, and the...

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ژورنال

عنوان ژورنال: Genetics and Molecular Research

سال: 2015

ISSN: 1676-5680

DOI: 10.4238/2015.june.18.15