Hypoxia-inducible erythropoietin expression: details matter
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چکیده
منابع مشابه
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma
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متن کاملHypoxia-inducible erythropoietin gene expression in human neuroblastoma cells.
Two human neuroblastoma (NB) cell lines, SH-SY5Y and Kelly, were found to express the gene for erythropoietin (EPO) in an oxygen (O(2))-dependent manner. However, NB cells had maximal production of EPO with lower partial pressure of O(2) values than the well-characterized hepatoma cell line HepG2. This maximal EPO expression was preceded by accumulation of the O(2)-sensitive alpha subunit of th...
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Induction of erythropoietin (Epo) expression under hypoxic conditions is mediated by the heterodimeric hypoxia-inducible factor (HIF)-1. Following binding to the 3* hypoxia-response element (HRE) of the Epo gene, HIF-1 markedly enhances Epo transcription. To facilitate the search for HIF-1 (ant)agonists, a hypoxiareporter cell line (termed HRCHO5) was constructed containing a stably integrated ...
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Iron demand in bone marrow increases when erythropoiesis is stimulated by hypoxia via increased erythropoietin (EPO) synthesis in kidney and liver. Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting internalization and degradation of ferroportin, the only known cellular iron exporter. Hypoxia suppresses hepcidin, thereby enhancing ...
متن کاملOntogenetic expression of erythropoietin and hypoxia-inducible factor-1 alpha genes in subterranean blind mole rats.
Blind subterranean mole rats of the Spalax ehrenbergi superspecies in Israel have evolved multiple adaptive strategies to face underground hypoxia. Hypoxia-inducible factor-1alpha (HIF-1alpha) and erythropoietin (Epo) are key factors in the development of normal erythropoiesis and angiogenesis. Here, we demonstrate via real-time polymerase chain reaction (PCR) quantification that Spalax fetal l...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2020
ISSN: 1592-8721,0390-6078
DOI: 10.3324/haematol.2020.261966