Hypoxia Conditioning for High-Altitude Pre-acclimatization

Molecular Mechanisms of Acclimatization to High Altitude Hypoxia: Role of Hypoxia Mimetic Cobalt Chloride

High-altitude hypoxia and preeclampsia.

The influence of hypoxia (lowered arterial blood and/or tissue PO2) on fetoplacental development and the role of hypoxia in preeclampsia are major research foci in perinatal biology. While animal and cell models are of utility, we do not know whether artificial hypoxic stimuli mimic the pathological conditions attributed to hypoxic stress in vivo; we cannot distinguish the effects of hypoxia fr...

Altitude preexposure recommendations for inducing acclimatization.

For many low-altitude (<1500 m) residents, their travel itineraries may cause them to ascend rapidly to high (>2400 m) altitudes without having the time to develop an adequate degree of altitude acclimatization. Prior to departing on these trips, low-altitude residents can induce some degree of altitude acclimatization by ascending to moderate (>1500 m) or high altitudes during either continuou...

Thromboelastometry and Platelet Function during Acclimatization to High Altitude.

Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting result...

Respiratory and circulatory changes during acclimatization to high altitude.

The studies of decreased barometric pressure made by Paul Bert (1) during the latter half of the nineteenth century may properly be considered as the beginning of modern knowledge of, and interest in, the effects of oxygen lack upon the human body. During the same period the rapid development of mountaineering as a sport produced a new occupational disease-altitude sickness, Or seroche as it wa...