Hypovitaminosis D, insulin resistance and hypertension in pregnancy

Association between insulin resistance, glucose intolerance, and hypertension in pregnancy.

There is an association between insulin resistance, glucose intolerance, and essential hypertension, but the relation between insulin resistance, glucose intolerance, and hypertension diagnosed during pregnancy is not well understood. Transient hypertension of pregnancy, the new-onset nonproteinuric hypertension of late pregnancy, is associated with a high risk of later essential hypertension a...

Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction.

BACKGROUND Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied. OBJECTIVE We investigated the relation of 25-hydroxyvitamin D [25(OH)D] concentrations to insulin sensitivity and beta cell function. DESIGN We enrolled 126 healthy, glucose-tolerant subjects living in California. Insulin sensitivity index (ISI) and first-...

P-183: TGF-? Level and Insulin Resistance during Normal Pregnancy

Insulin Resistance and Hypertension

Insulin resistance refers to the reduction in insulinmediated glucose uptake in insulin-sensitive tissues, specifically in skeletal muscle. As a compensatory response, hyperinsulinemia ensues to maintain normal blood glucose levels. In epidemiological studies, fasting insulin level is commonly used as a surrogate marker of insulin resistance. In normoglycemic subjects, fasting insulin correlate...

Insulin resistance and hypertension.

A common mechanism which may be involved in the development of hypertension in both type I and type II diabetes mellitus is a deficiency of insulin at the cellular level. Observations from a number of laboratories suggest that impaired cellular response to insulin rather than hyperinsulinemia predisposes to increased vascular smooth muscle tone (the hallmark of hypertension in the diabetic stat...