Hypothesis: Causes of Type 2 Diabetes in Progeroid Werner Syndrome

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Hypothesis: Causes of Type 2 Diabetes in Progeroid Werner Syndrome

The premature ageing Werner syndrome (WS) is characterized by the early onset of many age related phenotypes, including graying of hair, cataracts, atherosclerosis, cancer and type 2 diabetes. Type 2 diabetes (DM2) is the loss of blood glucose homeostastis, due to insulin resistance and a failure of acute glucose-stimulated insulin secretion (GSIS) by pancreatic cells. Early compensation for in...

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ژورنال

عنوان ژورنال: Open Longevity Science (Formerly 'The Open Aging Journal')

سال: 2008

ISSN: 1876-326X

DOI: 10.2174/1876326x00802010100