Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus
INTRODUCTION Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. This study assessed whether increased circulating plasma OPN (cOPN) precedes development of organ damage in pediatric systemic lupus erythematosus (pSLE) and compared it to circulating plasma neutrophil gelatinas...
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متن کاملPlasma osteopontin as a marker for future organ damage in pediatric systemic lupus erythematosus
Purpose Osteopontin (OPN) is a secreted phosphoprotein functioning in monocyte and T cell adhesion and migration. Expression of OPN in alternatively-activated macrophages has been implicated in post-inflammatory fibrosis of lung and kidney. In our previously conducted cross-sectional study of 72 pediatric SLE patients (pSLE; age of onset <18 years), increased circulating plasma OPN (cOPN) was o...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2018
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2018/8051972