Hypocapnia prolongs bradycardia induced by bupivacaine or levobupivacaine in isolated rat hearts
نویسندگان
چکیده
منابع مشابه
Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts
BACKGROUND The reversal efficacy of 2% lipid emulsion in cardiac asystole induced by different concentrations of bupivacaine is poorly defined and needs to be determined. METHODS Forty-two male Sprague-Dawley rats were randomly divided into seven groups: B40, B60, B80, B100, B120, B140 and B160, n = 6. The Langendorff isolated heart perfusion model was used, which consisted of a balanced perf...
متن کاملLipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships.
BACKGROUND The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined. METHODS Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendorff preparation. Cardiac function parameters were recorded during infusion. ...
متن کاملEvidence of Reversible Bradycardia and Arrhythmias Caused by Immunogenic Proteins Secreted by T. cruzi in Isolated Rat Hearts
RATIONALE Chagas cardiomyopathy, caused by the protozoan Trypanosoma cruzi, is characterized by alterations in intracellular ion, heart failure and arrhythmias. Arrhythmias have been related to sudden death, even in asymptomatic patients, and their molecular mechanisms have not been fully elucidated. OBJECTIVE The aim of this study is to demonstrate the effect of proteins secreted by T. cruzi...
متن کاملIsolated Rat Hearts
The present investigation studied the effect of increasing severities of ischemic injury on recovery of oxidative metabolism after reperfusion in isolated rat hearts perfused retrogradely with erythrocyte-containing medium. Hearts subjected to 60 minutes of low-flow ischemia (5% of control perfusion) exhibited delayed but sustained recovery of left ventricular pressure development during reperf...
متن کاملIsolated Rat Hearts
The effect of perfusate [Ca2+] on the function of cardiac sarcoplasmic reticulum (CSR) was assessed by the oxalate-supported Ca2' uptake rate of ventricular homogenates of isolated rat hearts maintained in a modified Langendorif preparation. The total Ca2' pumping activity of the CSR was determined by using 20 FM ruthenium red or 625 j±M ryanodine to close the CSR Ca2+ release channel. The homo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2008
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03034055