منابع مشابه
Hypertriglyceridemia
Hypertriglyceridemia (HTG) is commonly encountered in lipid and cardiology clinics. Severe HTG warrants treatment because of the associated increased risk of acute pancreatitis. However, the need to treat, and the correct treatment approach for patients with mild to moderate HTG are issues for ongoing evaluation. In the past, it was felt that triglyceride does not directly contribute to develop...
متن کاملApolipoprotein A5 and hypertriglyceridemia.
Hypertriglyceridemia is associated with increased risk of coronary heart disease (CHD) (1–5), and it is an integral component of the overlapping syndromes of familial combined hyperlipidemia, insulin resistance syndrome, atherogenic lipoprotein profile, and hyperapobetalipoproteinemia (6 ). More than one mechanism may be involved in the increased risk of CHD associated with increased serum trig...
متن کاملPancreatitis Induced by Hypertriglyceridemia
The detailed pathophysiological mechanisms involved in the progression of hypertriglyceridemia to pancreatitis are little known. Using an animal model we have found that the earliest detectable changes caused by hypertriglyceridemia consist of a selective degeneration of the mitochondria in the exocrine pancreas cells. This supports the view that an excess of free fatty acids deranges the mitoc...
متن کاملThe editor's roundtable: hypertriglyceridemia.
Dr. Friedewald has no conflicts to disclose. Dr Ballantyne has received research grants and honoraria from Amarin Pharma, Inc. and has also received research grants and served as a consultant and speaker for numerous other pharmaceutical companies. Dr. Bays has received research grants and served as an adviser to Amarin Pharma Inc. and has also received research grants and served as a consultan...
متن کاملHypertriglyceridemia in Transgenic Mice
We have generated transgenic mice expressing the human apolipoprotein CII (apoCI ) gene under the transcriptional control of the human cytochrome P450 IA1 (CYPIAl) promoter. Human apoCIt transgenic (HuCIITg) mice exhibited significant basal expression of the transgene (plasma apoCIl level = 26.1±4 mg/dl) and showed further induction of transgene expression after treatment with fl-naphthoflavone...
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ژورنال
عنوان ژورنال: The Journal of the American Board of Family Medicine
سال: 2006
ISSN: 1557-2625,1558-7118
DOI: 10.3122/jabfm.19.3.310