Hypermethylation of p16 and DAPK promoter gene regions in patients with non-invasive urinary bladder cancer
نویسندگان
چکیده
منابع مشابه
Hypermethylation of p16 and DAPK promoter gene regions in patients with non-invasive urinary bladder cancer
INTRODUCTION The aim of the study was to examine the frequency of methylation status in promoter regions of p16 and DAPK genes in patients with non-invasive bladder cancer. MATERIAL AND METHODS Forty-two patients (92.9% men, 73.8% smokers, 71.4% T1G1, 19.1% T1G2, 9.5% T1G3) and 36 healthy controls were studied. Isolation of genomic DNA from blood serum and methylation-specific PCR (MSP) were ...
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BACKGROUND/AIMS Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is one of the most popular research areas in recent years. DNA methylation, which is an epigenetic mechanism, occurs in the early stages of tumori...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2011
ISSN: 1734-1922
DOI: 10.5114/aoms.2011.23421