Hyperleucocytosis following G-CSF treatment for sulfasalazine-induced agranulocytosis

Clozapine-induced Agranulocytosis and Use of G-csf

Use of clozapine is attended with the serious though rare risk of agranulocytosis. Clozapineinduced agranulocytosis is reversible with the use of cytokines like granulocyte-colony stimulating factor (G-CSF). Reports of the haematological complication of clozapine have not been forthcoming from India though it has been in use for nearly three years. This report is on an young patient who develop...

Morphological features following G-CSF treatment.

RhG-CSF is widely used in hematology and oncology for the amelioration of chemotherapy induced neutropenia, for the restoration of neutrophil production after bone marrow transplantation, and for other conditions such as myelodysplastic syndromes, aplastic anemia and severe chronic neutropenia. Moreover, RhG-CSF is able to bring about a lot of functional and phenotype modifications in the induc...

First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.

Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role fo...

Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis.

Granulocyte colony-stimulating factor (G-CSF) levels in serum were determined by a highly-sensitive chemiluminescent enzyme immunoassay (limit of detection, 0.5 pg/ml) in 54 patients with Graves' disease including 6 patients complicated with methimazole-induced agranulocytosis. Serum G-CSF levels in patients with Graves' disease were not different from normal subjects and did not correlate with...

G-CSF treatment of chemotherapy induced neutropenia - Online supplement