Hyperhaploidy is a novel high-risk cytogenetic subgroup in multiple myeloma
نویسندگان
چکیده
منابع مشابه
Extramedullary Manifestation in Multiple Myeloma Bears High Incidence of Poor Cytogenetic Aberration and Novel Agents Resistance
Extramedullary disease (EMD) in multiple myeloma (MM) patients is an uncommon event and more attention was directed toward the feature of these patients. Cytogenetic aberration is an important characteristic of MM and is associated with patients' outcome. In this study, we aimed to compare the cytogenetic abnormality of patients with and without extramedullary manifestation, and to analyze the ...
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The bone marrows of fourteen patients with multiple myeloma containing a total of more than twenty scorable metaphase plates in all samples collected were subjected to cytogenetic study. In five of these an abnormal acrocentric marker chromosome with long arms the length of those of the B group was found in a num ber of the hyperdiploid cells. In two additional patients, this same abnormality m...
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This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
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EXPERIMENTAL DESIGN To determine whether the clinical benefit of complete remission (CR) may depend on prognostic subgroups of patients with multiple myeloma. PATIENTS AND METHODS Newly diagnosed patients with myeloma received a tandem autotransplant regimen. Using multivariate regression analyses, we examined the prognostic implications of time-dependent onset of CR on overall survival and e...
متن کاملCytogenetic studies in myeloma.
Chromosomes have been studied in cultures of nucleated peripheral blood cells in 30 patients with myeloma. Both unstimulated cultures and cultures stimulated by phytohemagglutinin (PHA) were examined in all cases. Mitoses were observed in 13 unstimulated cultures of peripheral blood from 12 cases, providing evidence for the presence of circulating abnormal cells in these patients. In 19 stimula...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2016
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2016.253