Hypercholesterolemia associated with splice-junction variation of inter-α-trypsin inhibitor heavy chain 4 (ITIH4) gene
نویسندگان
چکیده
منابع مشابه
ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection.
We have isolated from calf serum a protein with an apparent M(r) of 120,000. The protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. The response of this protein in th...
متن کاملRapid Communication : The Porcine Inter - α Trypsin Inhibitor - Heavy Chain 4 ( ITIH 4 ) Gene Maps to Chromosome 131
1The authors thank A. L. Archibald, M. F. Rothschild, and the EC PiGMaP group for distribution of DNA from the PiGMaP reference families, and D. Nicholson, C. Haley, and G. J. Lee for provision of database services and linkage analyses. Published as paper no. 11935, Journal Series, Agric. Res. Div., Univ. of Nebraska, Lincoln 68583-0908. 2To whom correspondence should be addressed: phone: (402)...
متن کاملSerum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia
Liver fibrosis and viremia are determinant factors for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. We aimed to investigate serum level of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and its relation to liver fibrosis and viremia in children with chronic HCV. ITIH4 was measured by ELISA in 33 treatment-naive children with proved chronic HCV and comp...
متن کاملIsolation and Characterization of the Promoter and Partial Enhancer Region of the Porcine Inter- -Trypsin Inhibitor Heavy Chain 4 Gene
A porcine genomic library was screened for clones containing the promoter of the major acute-phase protein in pigs, inter-trypsin heavy chain 4 (ITIH4). Following isolation of the promoter, a functional analysis was performed with Hep3B cells. The promoter was induced by interleukin-6 (IL-6) but not by IL-1 . However, IL-1 was shown to inhibit the IL-6-induced activation of the porcine ITIH4 pr...
متن کاملTwo RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10.
SOURCE AND DESCRIPTION OF CLONE : The 0.8 kb Eco RI / Bam HI fragment of lambda HuHITI-9 (1) used as a probe codes for human heavy chain H2 of the inter-alpha-trypsin inhibitor (2). POLYMORPHISMS : Kpn 1 (GGTAC/C) identifies one invariant band at 8.5 kb and a diaJlelic polymorphism with DNA fragments at 26.0 kb or 20.0 kb. Msp I (C/CGG) identifies three invariant bands at 2.35 kb, 2.1 kb and 1....
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2003
ISSN: 1434-5161,1435-232X
DOI: 10.1007/s10038-003-0101-8