Hyper-IgG4 disease: report and characterisation of a new disease

Hyper-IgG4 disease: report and characterisation of a new disease

BACKGROUND We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histologically by a lymphoplasmacytic inflammation with IgG4-positive cells and exuberant fibrosis, which leaves dense fibrosis on resolution. A typical example is idiopathic retroperit...

Kimura’s Disease: A Case Report and Review of Literatures

Kimura’s disease (KD) is a chronic inflammatory disorder primarily seen in male Asians during the second and third decades of life. Clinically, it presents as solitary or multiple subcutaneous nodules, predominantly in the head and neck region, typically in the pre auricular region, forehead, and scalp. The etiology of Kimura disease is still unknown. This disorder should be suspected when the ...

Perivascular fibrosis and IgG4-related disease: a case report.

Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized fibroinflammatory condition which can potentially involve any organ. Some characteristic histopathologic features with lymphoplasmacytic infiltrate, an increased number of IgG4+ cells, storiform fibrosis and obliterative phlebitis are the mainstay for diagnosis. Serum IgG4 levels often increase. We report the case of a patient wi...

Castleman’s Disease, a Case report

Introduction: Castleman's disease is a rare lymphoproliferative disorder which may be confused with other causes of lymphadenopathy. Case Report: Here we report a case of unicentric Castleman's disease presenting with cervical lymphadenopathy. The patient was treated with complete surgical excision of lesion and was disease free at the time of reporting this article. This case has been reported...

IgG4 syndrome: old disease, new perspective.