Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase
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چکیده
منابع مشابه
Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.
Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral protein synthesis by using [35S]methionine pulse-labeling at intervals throughout the infection ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1986
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.60.2.506-514.1986