Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice

The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to prodrug NFOH, also increases anti-T. cruzi activities (in vitro and in vivo), as well showed non-genotoxic (Ames micronucleus assays). In present study, we assessed effect NFOH vivo - acute Swiss C57Bl/6 experimental Chagas models. treatment started at 5 days post-infection during 20 consecutive (orally, once day, 150mg/kg), parasitaemia histopathology analysis were performed. both murine models, was able reduce parasitemia blood avoiding parasitic reactivation, immunosuppression period (dexamethasone 5mg/kg, 14 days), 100% mice, decrease tissue parasite nests, demonstrating absence amastigote forms all organs (100%) analyzed, data similar benznidazole (BZN). Therefore, results shown here pointing promising compound for further preclinical studies, being a high potential drug effective safe chemotherapy disease.