Hydroxyl Ion Movements across the Human Erythrocyte Membrane
نویسندگان
چکیده
منابع مشابه
Hydroxyl Ion Movements across the Human Erythrocyte Membrane
A stopped flow rapid reaction apparatus capable of following changes of +/-0.02 pH unit in 0.1 ml of solution in less than 0.005 sec has been developed, utilizing a commercially available pH-sensitive glass electrode. Using this instrument, extracellular pH at 37 degrees C was followed from less than 0.025 sec to 300 sec after mixing equal volumes of the following CO(2)-free solutions: (A) norm...
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Erythrocytes, which constitute more than 40% of the blood volume and about 3% of the body mass, are an important, although frequently neglected, detoxification organ. The main route of xenobiotic metabolism in erythrocytes goes through the glutathione conjugation process, and subsequently comprises removal of the conjugates via the membrane active transport systems. In human erythrocyte membran...
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We have measured the effects of oxygen tension on the transport of Na+, K+ and Cl- across the erythrocyte membrane of the lamprey Lampetra fluviatilis. The transport of each ion was affected by the oxygen tension of the medium. Hypoxic conditions (PO2 2 kPa) caused an increase in the acidification-induced influx of Na+ via Na+/H+ exchange. The influx of K+ was only slightly affected by the oxyg...
متن کاملRelationship of net chloride flow across the human erythrocyte membrane to the anion exchange mechanism
The parallel effects of the anion transport inhibitor DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonate) on net chloride flow and on chloride exchange suggest that a major portion of net chloride flow takes place through the anion exchange system. The "slippage" model postulates that the rate of net anion flow is determined by the movement of the unloaded anion transport site across the membra...
متن کاملMigration of Amino Acids across the Membrane of the Human Erythrocyte.
Before the work of Costantino, the erythrocyte was considered to be impermeable to ammo acids (1, 2). Costantino observed, however, a higher level in the red blood cell than in the serum of groups titratable in the presence of formaldehyde (3). He was also able to demonstrate by this method uptake by red cells in vitro of glycine, asparagine, and the mixture of amino acids contained in a casein...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1971
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.57.6.664