منابع مشابه
Synthesis and characterization of fatty hydroxamic acids from triacylglycerides.
In this study, fatty haydroxamic acids (FHAs), which have biological activities as antibiotics and antifungal, have been synthesized via refluxing of triacylglycrides, palm olein, palm stearin or corn oil with hydroxylamine hydrochloride. The products were characterized using the complex formation test of hydroxamic acid group with zinc(I), copper(II) and iron(III), various technique methods in...
متن کاملsynthesis and dissociation constants of calix(6)arene hydroxamic acids
calix(6)arene hydroxamic acids (iii) are synthesised for the first time by reactingcalix(6)arene acid chloride(ii) with substituted hydroxylamines at low temperature in the presence ofsodium bicarbonate. the p-carboxycalix(6)arene(i) is obtained by an acid catalysed condensationreaction of p-hydroxybenzoic acid and formaldehyde. these calixarenes are characterised by meltingpoint, uv, ir, 1h nm...
متن کاملTheoretical Studies on Hydroxamic Acids
Hydroxamic acids find many applications in chemistry and biology and have been the subject of many experimental investigations. Theoretical studies are not as frequent. However, the smallest homolog, formohydroxamic acid (FHA), has been studied at various levels, including high-level ab initio and density functional with large basis sets. All studies indicate that it exists as the Z-amide tauto...
متن کاملAntioxidant activity of NSAID hydroxamic acids.
In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0% and EC50 = 60.1 microg m...
متن کاملChemistry and Biology of Hydroxamic Acids
The action of salicylhydroxamic acid and its halogen derivatives against tuberculosis, fungi, trypanosomae, and the biosynthesis of cholesterol are described. Their hypoglycemic and phospholipid lowering actions are also mentioned. The author suggested, in 1948, the use of salicylhydroxamic acid I (X = Y = Z = R = H)—called SH—as an antitubercular agent [26]. The suggestion was based on the hyp...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2012
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar300216r