Hydrophobic Interactions Are Key To Drive the Association of Tapasin with Peptide Transporter Subunit TAP2
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولHydrophobic interactions in metalloporphyrin-peptide complexes.
The study of synthetic analogues of heme proteins has been thorough and successful.1 Despite many accomplishments, however, there remains a fundamental difference between the heme proteins themselves and the small molecules that mimic them; the analogues are generally not made from peptides, and the interactions between the heme and the protein remain largely unexplored.2 The few exceptions are...
متن کاملMolecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing.
The loading of antigen-derived peptides onto MHC class I molecules for presentation to cytotoxic T cells is a key process in adaptive immune defense. Loading of MHC I is achieved by a sophisticated machinery, the peptide-loading complex (PLC), which is organized around the transporter associated with antigen processing (TAP) with the help of several auxiliary proteins. As an essential adapter p...
متن کاملPolymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.
OBJECTIVES To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. RESULTS No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgr...
متن کاملAre transporter associated with antigen processing (TAP) and tapasin class I MHC chaperones?
Class I MHC heavy chains associate with many proteins in the endoplasmic reticulum, including TAP, calnexin, calreticulin, and the newly defined tapasin molecule. Recent studies have begun to resolve the nature of how these proteins interact with class I as well as the functional significance of each of these interactions. We propose here that TAP and tapasin are leading candidates to be highly...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2015
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1500246