Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Poly(dimethylsiloxane) (PDMS) has been widely employed in biomedical disciplines due to its several advantages, including biocompatibility, nontoxicity, and low-cost preparation. However, the intrinsic hydrophobicity of this material encourages biofouling reduces cell regulation capacity, thereby limiting applicability. The purpose study is explore surface modification functionalization PDMS PDMS-based biomaterials improve their properties for applications. content review organized based on physical chemical strategies hydrophilicity enhance antibiofouling immunomodulation modulation biomaterials. Future developments area are also discussed.