Hydrophilic Antimicrobial Coatings for Medical Leathers from Silica-Dendritic Polymer-Silver Nanoparticle Composite Xerogels

Hybrid organic-inorganic (dendritic polymer-silica) xerogels containing silver nanoparticles (Ag Nps) were developed as antibacterial leather coatings. The preparation method is environmentally friendly and based on two biomimetic reactions. Silica gelation spontaneous Ag Nps formation both mediated by hyperbranched poly (ethylene imine) (PEI) scaffolds of variable Mw (2000–750,000). precursor hydrogels was monitored dynamic light scattering (DLS). chemical composition the assessed infrared spectroscopy (IR) energy-dispersive X-ray (EDS), while uniformity coatings established scanning electron microscopy (SEM). release properties coated samples their overall behavior in water comparison to untreated analogs investigated Ultraviolet-Visible (UV-Vis) spectroscopy. Antibacterial activity tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, antibiofilm epidermidis, Acinetobacter baumannii, Enterococcus faecalis, SARS-CoV-2 clinical isolate employed for first estimation antiviral potential. Toxicity evaluated using Jurkat E6.1 cell line. Finally, water-contact angle measurements implemented determine enhancement surface hydrophilicity caused these composite layers. final advanced products are intended use medical applications.