Hydrogen sulphide synthesis in GtoPdb v.2023.1

Hydrogen sulfide is a gasotransmitter, with similarities to nitric oxide and carbon monoxide. Although the enzymes indicated below have multiple enzymatic activities, focus here generation of hydrogen sulphide (H2S) characteristics are described accordingly. Cystathionine β-synthase (CBS) cystathionine γ-lyase (CSE) pyridoxal phosphate (PLP)-dependent enzymes. 3-mercaptopyruvate sulfurtransferase (3-MPST) functions generate H2S; only CAT PLP-dependent, while 3-MPST not. Thus, this third pathway sometimes referred as PLP-independent. CBS CSE predominantly cytosolic enzymes, found both in cytosol mitochondria. For an authoritative review on pharmacological modulation H2S levels, see Szabo Papapetropoulos, 2017 [8].