Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome
نویسندگان
چکیده
منابع مشابه
NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis.
OBJECTIVE To investigate the relationship between NLRP3 and the pathogenesis of collagen-induced arthritis. METHODS We used the collagen-induced arthritis (CIA) mouse model. The mice were divided into two groups: the model group (CIA, n = 16) and the control group (Normal, n = 8). The mice were sacrificed seven weeks after immunization. The arthritis score and imaging evaluation (X-rays, Micr...
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Mycobacterium tuberculosis (Mtb) remains a significant menace to global health as it induces granulomatous lung lesions and systemic inflammatory responses during active tuberculosis (TB). Micheliolide (MCL), a sesquiterpene lactone, was recently reported to have a function of relieving LPS-induced inflammatory response, but the regulative role of MCL on the immunopathology of TB still remains ...
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The Nod-like receptor protein (NLRP)-3 inflammasome/IL-1β pathway is involved in the pathogenesis of various inflammatory skin diseases, but its biological role in wound healing remains to be elucidated. Since inflammation is typically thought to impede healing, we hypothesized that loss of NLRP-3 activity would result in a downregulated inflammatory response and accelerated wound healing. NLRP...
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Inflammasomes play important roles in the pathogenesis of tumors, but the roles of NLRP3 inflammasome in the lymphoma remain unclear. Activated NLRP3 inflammasome induces the maturation of its effector cytokine IL-18 which functions in the development of cancer. Here, we investigated the polymorphism and expression of NLRP3 inflammasome related genes and explored their function in lymphoma. We ...
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helminthic infections, and allergy. They are closely associated with recruiting and amplifying T helper 2 (Th2) lymphocyte response in contrast to Th1asscoiated CAMs. Wide donor-to-donor variability of human primary monocytes and their limited life span in vitro is a current impediment to investigating human AAM biology and their contribution to enhancing Th2mediated pathologic inflammation fou...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2020
ISSN: 1449-2288
DOI: 10.7150/ijbs.47595