Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice
نویسندگان
چکیده
منابع مشابه
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
The mammalian stress sensor IRE1α plays a central role in the unfolded protein, or endoplasmic reticulum (ER), stress response by activating its downstream transcription factor XBP1 via an unconventional splicing mechanism. IRE1α can also induce the degradation of a subset of mRNAs in a process termed regulated IRE1-dependent decay (RIDD). Although diverse mRNA species can be degraded by IRE1α ...
متن کاملFormononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity
To examine the effects of formononetin (FMN) on Acetaminophen (APAP)-induced liver injury in vitro and in vivo. Human non-tumor hepatic cells LO2 were pretreated with either vehicle or FMN (20, 40 μM), for 6 h, followed by incubation with or without APAP (10 mM) for 24 h. In an in vivo assay, male BALB/c mice were randomly divided into four groups: (1) control group; (2) APAP group; (3) APAP + ...
متن کاملLipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatotoxicity.
Acetaminophen (APAP)-induced liver injury remains the main cause of acute liver failure in the United States. Our previous work demonstrated that LPS binding protein (LBP) knockout mice are protected from APAP-induced hepatotoxicity. LBP is known to bind avidly to LPS, facilitating cellular activation. In this study, we sought to specifically inhibit the interaction between LBP and LPS to defin...
متن کاملCarnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice
Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment si...
متن کاملEffect of Viola Extract on Acetaminophen-induced Hepatotoxicity in Mice
Introduction: Acetaminophen is a common analgesic that is toxic to the liver in the case of high dose and antioxidants such as herbs can partially inhibit the harmful effects of high dose of such substances. Materials and Methods: In this study, 42 mice weighing 25-30 g were randomly divided into six groups (n=7). The first group as the control group received 1 ml/kg (0.5 ml/kg 12 hours apart)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2015
ISSN: 1007-9327
DOI: 10.3748/wjg.v21.i14.4195