Hydrogel Films of Citric Acid Cross-linked Hydroxypropyl Methylcellulose/Methylcellulose for Hydrophilic Drug Delivery

Abstract: Aim: To develop hydrogel films for hydrophilic drug delivery with citric acid-cross-linked Hydroxypropyl Methylcellulose (HPMC) and (MC). Materials Methods: The existing study is concerned the development of HPMC/MC employing acid as a cross-linking agent in order to accomplish loading while simultaneously releasing drugs (ciprofloxacin hydrochloride). Thermal analysis ATR-FTIR spectroscopy were used explore films. Drug loading, content, swelling ratio, vitro release, carboxyl hemolytic assay all measured on Cross-linking through ester was revealed by spectra, whereas crosslinking means formation validated thermal well SEM. Results: A good equilibrium ratio 14.71 found phosphate buffer pH 7.4. With low swelled most showed better release. addition methylcellulose aided creation firm, homogeneous dispensing ciprofloxacin hydrochloride. Conclusion: films' biocompatibility demonstrated using experiment. It observed that had been cross-linked tendency sustain release up 4 hr. Keywords: methylcellulose, Methylcellulose, Citric acid, Hydrophilic drug, Cross-linked films, Ciprofloxacin hydrochloride, delivery.