Hydrogel assistant synthesis of new Ti-MOF cross-linked oxidized pectin and chitosan with anti-breast cancer properties

Breast cancer is one of the most common diseases modern age. Although many methods for its treatment have been reported so far, report and synthesis new compounds based on technologies, especially nanotechnology, important. One laboratory evaluating anticancer properties in vitro MTT method (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide). In this study, anti-breast activity newly synthesized (Titanium Metal-Organic Framework) Ti-MOF cross-linked oxidized pectin chitosan hydrogel, which uses biopolymers structure, was investigated. The results showed that synthetic nanopolymer had cell proliferation viability 27% more than control (the half maximal inhibitory concentration) IC 50 111 μg/mL against breast cells. Before evaluation, structure pectin, hydrogel confirmed by (X-Ray Diffraction) XRD pattern (Fourier Transform Infrared) FT-IR spectrum (Energy-dispersive X-ray) EDAX spectroscopy, N 2 adsorption/desorption isotherm (Scanning Electron Microscope) Scanning Microscope images. identification characterization range nanoparticles. peaks expected functional groups reactant elements were observed energy-dispersive X-ray spectroscopy final product. High physicochemical capabilities such as uniform morphology, crystallization particles, high specific surface area from observed. unique can be attributed to appropriate carried out study.