Hybrid stochastic simulations of intracellular reaction–diffusion systems
نویسندگان
چکیده
منابع مشابه
Stochastic hybrid modeling of intracellular calcium dynamics.
Deterministic models of biochemical processes at the subcellular level might become inadequate when a cascade of chemical reactions is induced by a few molecules. Inherent randomness of such phenomena calls for the use of stochastic simulations. However, being computationally intensive, such simulations become infeasible for large and complex reaction networks. To improve their computational ef...
متن کاملHybrid simulations of stochastic reaction-diffusion processes for modeling intracellular signaling pathways.
In the intracellular environment, signaling takes place in a nonideal environment that is spatially heterogeneous and that is noisy, with the noise arising from the low copy numbers of the signaling molecules involved. In this paper, we model intracellular signaling pathways as stochastic reaction-diffusion processes and adapt techniques commonly used by physicists to solve for the spatiotempor...
متن کاملStochastic Modeling for Hybrid Network Simulations
Network-Centric Warfare (NCW) is an objective of the Department of Defense (DoD). By networking large numbers of soldiers, sensors, vehicles, and other equipment, NCW will create an explosion of data in DoD networks. By the same token, Mobile ad hoc networks (MANET) represent a critical technology for the Armys NCW vision. MANETS are currently an unproven technology that has not been modeled at...
متن کاملModeling Stochastic Hybrid Systems
Stochastic hybrid systems arise in numerous applications of systems with multiple models; e.g., air traffc management, flexible manufacturing systems, fault tolerant control systems etc. In a typical hybrid system, the state space is hybrid in the sense that some components take values in a Euclidean space, while some other components are discrete. In this paper we propose two stochastic hybrid...
متن کاملBiochemical simulations: stochastic, approximate stochastic and hybrid approaches
Computer simulations have become an invaluable tool to study the sometimes counterintuitive temporal dynamics of (bio-)chemical systems. In particular, stochastic simulation methods have attracted increasing interest recently. In contrast to the well-known deterministic approach based on ordinary differential equations, they can capture effects that occur due to the underlying discreteness of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Computational Biology and Chemistry
سال: 2009
ISSN: 1476-9271
DOI: 10.1016/j.compbiolchem.2009.03.002