Hybrid modeling of biological networks: mixing temporal and qualitative biological properties
نویسندگان
چکیده
منابع مشابه
Hybrid Modeling of Gene Regulatory Networks: Mixing Temporal and Qualitative Biological Properties
Modeling gene regulatory network is a difficult task. Experiments often fail at giving enough information for parameterizing existing models. We propose herein a dedicated hybrid modeling. To overcome the lack of quantitative information, our modeling focuses on (i) the biological compound product signs and (ii) the temporal properties associated with the biological effects of the interactions....
متن کاملSymbolic Systems Biology: Hybrid Modeling and Analysis of Biological Networks
How do living cells compute and control themselves, and communicate with their environment? We describe the modeling and analysis of dynamic and reactive biological systems involving both discrete and continuous behaviors, to help begin to answer that question. Continuous components arise as differential equations specifying how the concentrations of various molecular species evolve over time. ...
متن کاملNeural Networks and Biological Modeling
is the jacobian matrix of F . If this matix has n distinct eigenvalues λk (real or complex), the system can be diagonalized, and the solutions can be expressed as combinations of exponentials of the form ek. Therefore, x − x∗ → 0 if all the eigenvalues have a negative real part. If one or more eigenvalues have positive real part, |x− x∗| → ∞. Therefore, • The fixed point x∗ is stable if all the...
متن کاملTemporal and Structural Analysis of Biological Networks
Our project introduces a graph-based relational learning approach using graph-rewriting rules for temporal and structural analysis of biological networks changing over time. The analysis of dynamic biological networks is necessary to understand life at the system-level, because biological networks continuously change their structures and properties while an organism performs various biological ...
متن کاملBiological Neuronal Networks, Modeling Of
In recent decades, since the seminal work of A. L. Hodgkin and A. F. Huxley (1), the study of the dynamical phenomena emerging in a network of biological neurons has been approached by means of mathematical descriptions, computer simulations (2,3), and neuromorphic electronic hardware implementations (4). Several models have been proposed in the literature, and a large class of them share simil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2010
ISSN: 1752-0509
DOI: 10.1186/1752-0509-4-79