Hyaluronan and Tumor Growth

Hyaluronan promotes tumor lymphangiogenesis and intralymphantic tumor growth in xenografts.

Hyaluronan (HA), a high molecular weight glycosaminoglycan in the extracellular matrix, has been implicated in the promotion of malignant phenotypes, including tumor angiogenesis. However, little is known about the effect of HA on tumor-associated lymphangiogenesis. In this study, mouse hepatocellular carcinoma Hca-F cells combined with or without HA were injected subcutaneously into C3H/Hej mi...

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer growth and the tumor microenvironment. Overexpression of HAS3 increased hyaluronan synthesis in BxPC-3 pancreatic cancer cells. In vivo, overexpression of HAS3 led to faster growing xenograft tumors with abundant extra...

Consequences of Hyaluronan Metabolism on Cell Cycle Progression in Prostate Tumor Growth and Metastasis

Inhibition of Tumor Growth and Lung Metastasis of Osteosarcoma in Vivo by Hyaluronan Oligosaccharides

Introduction Hyaluronan (HA) is a large, linear, negatively charged polysaccharide with molecular weights ranging 10-10, interacting with pericellular matrix, and regulating tumor cell biology, such as proliferation, motility, and invasiveness. Manipulation of HA synthesis alters the hyaluronan rich-matrix and malignant properties (1). Numerous studies suggest that HA interacts with specific ce...

Hyaluronan Tumor Cell Interactions in Prostate Cancer Growth and Survival PRINCIPAL INVESTIGATOR:

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