Huntingtin associated protein 1 and its functions
نویسندگان
چکیده
منابع مشابه
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
HAP1 (Huntingtin-associated protein 1) consists of two alternately spliced isoforms (HAP1A and HAP1B, which have unique C-terminal sequences) and participates in intracellular trafficking. The C terminus of HAP1A is phosphorylated, and this phosphorylation was found to decrease the association of HAP1A with kinesin light chain, a protein involved in anterograde transport in cells. It remains un...
متن کاملHuntingtin and Huntingtin - Associated Protein 1 Influence Neuronal Calcium Signaling Mediated
Only one HAP1 isoform has been identified in humans, and this Vancouver, British Columbia Canada is most similar to rodent HAP1A (Li et al., 1998b). Association of HAP1 with hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Li et al., 2002), the p150Glued subunit of dynactin (Engelender et al., 1997; Summary Li et al., 1998a), and the Rac1 guanine nucleotide exchange factor Ka...
متن کاملHuntingtin-associated protein 1: a potential biomarker of breast cancer.
It is reported that patients with Huntington's disease (HD) have a low incidence of cancer. In this study, we investigated the expression of huntingtin-associated protein 1 (HAP1), the ligand of HD's production, in breast tumor and normal tissues. We found that HAP1 expression was significantly lower in tumor compared to normal tissues. We then transfected the HAP1 gene into the breast cancer l...
متن کاملHuntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1
Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin (Htt). The type 1 inositol (1,4,5)-triphosphate receptor (InsP3R1) is an intracellular calcium (Ca2+) release channel that plays an important role in neuronal function. In a yeast two-hybrid screen with the InsP3R1 carboxy terminus, we isolated Htt-associated protein-1A (HAP1A). We show that an InsP3R1-HAP1A-Htt ...
متن کاملHuntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in brain development and synaptic plasticity. It is synthesized as a precursor (pro-BDNF), sorted into the secretory pathway, transported along dendrites and axons, and released in an activity-dependent manner. Mutant Huntingtin with expanded polyglutamine (polyQ) and the V66M polymorphism of BDNF reduce the dendritic distribution an...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2009
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.3.1.7511