Human umbilical cord MSC‑derived hepatocyte growth factor enhances autophagy in AOPP‑treated HK‑2 cells
نویسندگان
چکیده
منابع مشابه
Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor
Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. Materials and Methods: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, ...
متن کاملHepatocyte growth factor modified human umbilical cord mesenchymal stem cells accelerate the recovery of mouse hepatic injury
Aim: MSC-based therapies have been accepted as a promising approach for treating liver injury. Here we aimed to investigate the effect of hepatocyte growth factor(HGF) modified human umbilical cord MSCs (HGF-hucMSCs) on mouse hepatic injury. Methods: HGF transduction to hucMSCs by using adenovirus-HGF was prepared. HGF-hucMSCs were transplanted into carbon tetrachloride (CCl4)-injured mice. Rev...
متن کاملIn-vitro Differentiation of Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells to Insulin-Producing Cells
Background & Objective: Diabetes is a major chronic metabolic disease in the world. Islet transplantation is a way to treat diabetes. Unfortunately, this method is restricted due to graft rejection and lack of donor islets. Mesenchymal Stem Cells (MSCS) have the ability to differentiate into Insulin-Producing Cells (IPCs). In this study, Human Umbilical Mesenchymal Stem Cells (HUMSCS) were in...
متن کاملInduction of hepatocyte‐like cells from human umbilical cord‐derived mesenchymal stem cells by defined microRNAs
Generating functional hepatocyte-like cells (HLCs) from mesenchymal stem cells (MSCs) is of great urgency for bio-artificial liver support system (BALSS). Previously, we obtained HLCs from human umbilical cord-derived MSCs by overexpressing seven microRNAs (HLC-7) and characterized their liver functions in vitro and in vivo. Here, we aimed to screen out the optimal miRNA candidates for hepatic ...
متن کاملP 82: The Transplantation of Human Umbilical Cord Mesenchymal Stem Cells in Neonatal Strokes
Brain injuries that caused by strokes (result of intra partum ischemia) are a frequent cause of prenatal mortality and morbidity with limited therapeutic options. Transplanting human mesenchymal stem cells (hmscs) indicates improvement in hypoxic Ischemic brain injury (HIBD) by secretion growth factor stimulating repair processes (Hmscs) known as multi potent cells which isolated from bone marr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2020
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2020.8998