Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.
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Basic fibroblast growth factor stimulates corneal endothelial cell growth and endothelial wound healing of human corneas.
PURPOSE To determine the dose response of human recombinant basic fibroblast growth factor (bFGF) on mitogenic activity, and the supplementary role of serum in cultured bovine and human corneal endothelial cells (BCECs, HCECs). To investigate the effect of bFGF on endothelial wound healing of human corneas in vitro. METHODS In cell culture, DNA synthesis was assessed by 3H-thymidine incorpora...
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Endothelial progenitor cells (EPC) can differentiate into both endothelial cells and contractile smooth muscle cells (SMC). Previously we reported that TR-BME2 cells, a model for EPC, developed contractile SMC-like characteristics in culture medium deprived of endothelial cell growth factors (ECGF). The aim of the present study was to clarify the effect of one of these factors, basic fibroblast...
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THE HYALOCYTES ARE MORE NUMEROUS IN THE POSTERIOR CHAMBER THANTHEYARElNTHEVITREOUS,AND?HBYDONOTREACTWllHAN ANTIBODY TO RABBK MACROPHAGES. HADDAD A. and AND& J.C. _ Fat. Medicina de Ribeiti Preto, USP, Brazil. Purpm To dctermux the distribution and nahue of free cells inslde the eye chambers. Methods The cdl uwm were performed on IS n0n-mnsecutive par&n sech(yIs per eye (starned ~10th H.E.) of 1...
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Background: Vascular endothelial growth factor-A (VEGF-A), an endothelial cell-specific mitogen produced by various cell types, plays important roles in cell differentiation and proliferation. In this study we investigated the effect of recombinant VEGF-A on differentiation of mesenchymal stem cells (MSCs) to endothelial cells (ECs). Methods: VEGF-A was expressed in E. coli BL21 (DE3) and BL21...
متن کاملCLINICAL SCIENCE Uveal melanomas express vascular endothelial growth factor and basic fibroblast growth factor and support endothelial cell growth
Background: Tumour microvascularity is a significant determinant of prognosis for a large number of different tumours, including uveal melanoma. The development of blood vessels within these and other tumours is partly controlled by soluble pro-angiogenic cytokines, of which basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF) are the best described. Methods: Be...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.8.2448