Human tumor antigens recognized by T lymphocytes.
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چکیده
منابع مشابه
Human tumor antigens recognized by T lymphocytes
W e have come a long way since the identification of the first human tumor antigen recognized by autologous CTL. This report provides a brief appraisal of these antigens and their potential for cancer immunotherapy. Our comments will be restricted to nonviral antigens. The initial work carried out on mouse tumors revealed two possible mechanisms for generating new antigens that might be suflfic...
متن کاملCommentary Human Tumor Antigens Recognized by T Lymphocytes
W e have come a long way since the identification of the first human tumor antigen recognized by autologous CTL. This report provides a brief appraisal of these antigens and their potential for cancer immunotherapy. Our comments will be restricted to nonviral antigens. The initial work carried out on mouse tumors revealed two possible mechanisms for generating new antigens that might be suflfic...
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Tumour-specific cytolytic T-lymphocytes (CTLs) have been obtained in several human tumour types, mainly melanoma. By using a genetic approach based on the transfection of genomic or cDNA libraries, the genes encoding a number of human tumour antigens have been cloned. This has led to the identification of antigenic peptides presented by tumour cells on various HLA class-I molecules. On the basi...
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T cells may recognize glycolipids and lipids of bacterial and self origin associated with the CD1 antigen-presenting molecules. Understanding the mechanisms governing CD1-self glycolipid interaction will provide information on the molecular rules of glycolipid presentation and suggest new approaches to immunotherapy.
متن کاملVaccination of Cancer Patients with Tumor Antigens Recognized by T Lymphocytes
It is now generally recognized that human tumors bear antigens that can be recognized by T lymphocytes of cancer patients. The approach that led to the identification of these antigens was based on in vitro stimulation of T lymphocytes of cancer patients with irradiated cells of the autologous tumor. This provided cytolytic T lymphocytes (CTL) clones that were capable of lysing with great speci...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1996
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.183.3.725