Human TSLP-Educated DCs
نویسندگان
چکیده
منابع مشابه
Plasmacytoid DCs, exposed to TSLP in synergy with TLR ligands, acquire significant potential towards Th2 polarization
BACKGROUND Thymic stromal lymphopoietin (TSLP) has been reported to activate myeloid dendritic cells (mDCs) to induce Th2 T lymphocyte responses. Its effect on plasmacytoid dendritic cells (pDCs) with TLR ligands has not yet been studied. We investigated the effects of TSLP and TLR ligands on mDCs and pDCs subsets. MATERIAL AND METHODS Myeloid dendritic cells (mDC) and plasmacytoid dendritic ...
متن کاملHepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice
Liver dendritic cells (DCs) display immunosuppressive activities and inhibit the CD4+ T cell response. The present study assessed whether and how liver DCs suppress CD8+ T cells. We found that bone marrow-derived mature DCs incubated with liver stromal cells were characterized by a longer life span, reduced CD11c, IA/IE, CD80, CD86, and CD40 expression, and increased CD11b expression. These uni...
متن کاملCellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells.
Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface. In humans, aberrant TSLP expression is observed in allergic tissues, such as lesional skins of atopic dermatitis, lungs of asthmatics, nasal mucosa of atopic rhinitis and nasal polyps, and ocular surface of allergic keratoc...
متن کاملTSLP-tickled mast cells
If you suffer a skin allergy, don’t be so quick to blame your T cells; they might not be behind it. Allakhverdi and colleagues now show on page 253 that mast cells, activated by a cytokine from epithelial cells, can jumpstart T cell–independent inflammation. Skin and epithelial cells irritated by allergens or by injury produce a cytokine called thymic stromal lymphopoietin (TSLP). This cytokine...
متن کاملDCS Document
This paper describes a relatively simple way of allowing a brain model to selforganise its concept patterns through nested structures. For a simulation, time reduction is helpful and it would be able to show how patterns may form and then fire in sequence, as part of a search or thought process. It uses a very simple equation to show how the inhibitors in particular, can switch off certain area...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2008
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2008.12