Human T cell variations

Allelic Variations in the Human T Cell Receptor

Two cell surface molecular structures participate in the specific recognition of a vast number of different peptide antigens by T lymphocytes. MHC-encoded molecules bind peptide fragments of antigenic material in an antigen binding groove (1). On T cells, TCR, predominantly ofthe ac/o chain variety, specifically recognize the antigenic peptide presented by MHC-encoded molecules (2). MHC-encoded...

Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16

Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...

Development of a Stable Cell Line, Overexpressing Human T-cell Immunoglobulin Mucin 1

Background: Recent researches have demonstrated that human T-cell immunoglobulin mucin 1 (TIM-1) glycoprotein plays important roles in regulation of autoimmune and allergic diseases, as well as in tumor immunity and response to viral infections. Therefore,targeting TIM-1 could be a potential therapeutic approach against such diseases. Objectives: In this study, we aimed to express TIM-1 protein...

Study of the Association Between Human T-cell Lymphotropic Virus Type I Infection and Lichen Planus

Stimulation of Camel Polyclonal Antibody against Human T cell Immunoglobulin and Mucin 3

Background: T cell Immunoglobulin, Mucin (TIM)-3, is a type I transmembrane glycoprotein belonging to TIM family. This receptor expresses on T helper type 1 (Th1) cells that binds to galectin-9 (Gal9); inducing an inhibitory signal. As a result, apoptosis of Th1 cells occurs and cytotoxicity of CD8 T cells becomes evident in vitro. Therefore, this immunomodulatory molecule may ...