Human T cell responses to β-galactosidase

Human T-cell responses to the glucosyltransferases of Streptococcus mutans.

We previously reported differential humoral responses to glucosyltransferases (GTFs), with significantly higher saliva and serum antibody levels to GtfD than to GtfB or GtfC. To test the hypothesis that cellular immune responses to these molecules also may differ, peripheral blood mononuclear cell (PBMC) and T-cell proliferative responses in young adults and children with distinct genetic backg...

Human T-cell responses to vaccinia virus envelope proteins.

One approach for a safer smallpox vaccine is to utilize recombinant subunits rather than live vaccinia virus (VACV). The products of the VACV envelope genes A27L, L1R, B5R, and A33R induce protective antibodies in animal models. We propose that proteins that elicit T-cell responses, as well as neutralizing antibodies, will be important to include in a molecular vaccine. To evaluate VACV-specifi...

In vitro human T cell responses to diphencyprone.

Conflicts of interest: The authors declare no conflict of interest. Funding: This work was supported by internal departmental research funds. C. Lai is a Wellcome Trust Research Training Fellow. viral warts and alopecia areata (1–4). It is also used as an experimental tool for investigatation of human immune responses; the contact allergic reactions elicited by DPCP patch tests can be quantifie...

Healthy Human T-Cell Responses to Aspergillus fumigatus Antigens

BACKGROUND Aspergillus fumigatus is associated with both invasive and allergic pulmonary diseases, in different hosts. The organism is inhaled as a spore, which, if not cleared from the airway, germinates into hyphal morphotypes that are responsible for tissue invasion and resultant inflammation. Hyphae secrete multiple products that function as antigens, evoking both a protective (T(H)1-T(H)17...

T Cell Responses in Human Leprosy