Human T Cell Clones

Panel of Human Proliferative T Cell Clones'

Lymphokine regulation of CD45R expression on human T cell clones

Whether the expression of higher molecular weight isoforms of the T-200 complex represents different lineages of T cells and/or a sequential stage of the differential pathway of T cells has been unclear. Understanding T cell expression of higher molecular weight isoforms of the T-200 complex (CD45R) may be important because of their association with regulation of immune responses. By direct sin...

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

Isolation of peptide-specific T-cell clones is highly desirable for determining the role of T-cells in human disease, as well as for the development of therapies and diagnostics. However, generation of monoclonal T-cells with the required specificity is challenging and time-consuming. Here we describe a library-based strategy for the simple parallel detection and isolation of multiple peptide-s...

Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones.

We have prepared a detergent extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells that is recognized by T cells from mice immunized with viable organisms or with the extract. A 62-kd antigen from this extract has been isolated and has been shown to be antigenic and to confer protective immunity in mice. In this study, we examined the in vitro proliferative response...

1436 Tolerance in T Helper Cell Clones

From the Division of Immunologic Oncology, Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington D.C. 20007," the Department of Immunology and the Committee for the Study of Molecular Genetics, Research Institute of Scripps Clinic, LaJolla, California 92037; and the Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College L...