Human RORγt+CD34+ Cells Are Lineage-Specified Progenitors of Group 3 RORγt+ Innate Lymphoid Cells
نویسندگان
چکیده
منابع مشابه
Gata3 drives development of RORγt+ group 3 innate lymphoid cells
Group 3 innate lymphoid cells (ILC3) include IL-22-producing NKp46(+) cells and IL-17A/IL-22-producing CD4(+) lymphoid tissue inducerlike cells that express RORγt and are implicated in protective immunity at mucosal surfaces. Whereas the transcription factor Gata3 is essential for T cell and ILC2 development from hematopoietic stem cells (HSCs) and for IL-5 and IL-13 production by T cells and I...
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ژورنال
عنوان ژورنال: Immunity
سال: 2014
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2014.11.010