Human reproductive failure I: Immunological factors

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Human reproductive failure I: immunological factors.

Human reproductive failure may be a consequence of aberrant expression of immunological factors during pregnancy. Although the relative importance of immunological factors in human reproduction remains controversial, substantial evidence suggests that human leukocyte antigens (HLA), antisperm antibodies, integrins, the leukaemia inhibitory factor (LIF), cytokines, antiphospholipid antibodies, e...

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I-16: The Immunological Aspect of Implantation Failure

The success of reproduction, although gradually increasing over the years, many couples also had been left frustrated following repeated failed attempts. Clinicians who treated unsuccessful couples often face a challenge. The probable causes of repeated IVF failures classified as: reduced endometrial receptivity, embryonic defects or multifactorial causes. Intrauterine and endometrial integrity...

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Immunological Testing and Interventions for Reproductive Failure

Reproductive failure is defined as the inability to conceive or to carry a pregnancy to term. Recurrent miscarriage and infertility are the two major categories of reproductive failure. It has been suggested that some cases of human reproductive failure may be the consequence of immunological abnormalities. A panel of immunological testing has been advocated and several immunotherapies have bee...

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Human Papillomavirus and Cancer - Immunological Consequences of MHC Class I Down-Regulation

Few studies have been conducted on the causative factors associated with the development of cancer. Infection by high risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers. HPV is capable of evading immune system and establishing persistent infections. Prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

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Background: The process of implantation involves the interaction of the human embryo and the uterine epithelium. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Management of repeated implantation failure despite transfer of good-quality embryos still rema...

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ژورنال

عنوان ژورنال: Human Reproduction Update

سال: 2001

ISSN: 1355-4786,1460-2369

DOI: 10.1093/humupd/7.2.113