منابع مشابه
Liquid crystalline human recombinant collagen: the challenge and the opportunity.
Collagen is a key component of the extracellular matrix, and by far the most prominent constituent of all load-bearing tissues. Its abundance and self-assembly capacities render it a practical scaffold material for tissue repair and regeneration applications. However, some difficulties exist in artificially regenerating functional collagen structures to match native tissues and their respective...
متن کاملHuman recombinant type I collagen produced in plants.
As a central element of the extracellular matrix, collagen is intimately involved in tissue development, remodeling, and repair and confers high tensile strength to tissues. Numerous medical applications, particularly, wound healing, cell therapy, bone reconstruction, and cosmetic technologies, rely on its supportive and healing qualities. Its synthesis and assembly require a multitude of genes...
متن کاملActivity of two-chain recombinant human cytomegalovirus protease.
The human cytomegalovirus UL80 protease was expressed in Escherichia coli and purified by metal-chelate chromatography using a histidine tag engineered at the amino terminus. Cleavage of the 30-kDa protease at an internal site, VEA/A144, resulted in the recovery of 16- plus 14-kDa two-chain protease. The amino-terminal 16-kDa chain and the carboxyl-terminal 14-kDa chain remained associated as a...
متن کاملCollagen chain composition and collagen gene expression in acne keloids.
Keloids are thick scars that grow beyond the boundaries of the original skin damage. Most lesions appear within one year of skin inflammation including burns, surgery and acne vulgaris. They are characterized by an excessive accumulation of extracellular mamx components. Keloid waning results from increased activity of fibroblasts in the dermis with imbalance between synthesis and breakdown of ...
متن کاملTissue-engineered recombinant human collagen-based corneal substitutes for implantation: performance of type I versus type III collagen.
PURPOSE To compare the efficacies of recombinant human collagens types I and III as corneal substitutes for implantation. METHODS Recombinant human collagen (13.7%) type I or III was thoroughly mixed with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide. The final homogenous solution was either molded into sheets for in vitro studies or into implants with the appropriate...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.48.30083